Pharmacology & ToxicologyJournal of Medicinal ChemistryPeer-reviewed
Development of Potent G Protein Pathway-Biased GPR183 Agonists
Kaustubh R. Bhuskute, Asmita Manandhar, Viktoria M. S. Kjær…·Elisabeth Rexen Ulven
This paper develops potent G protein-biased GPR183 agonists with low nanomolar potency and complete Gi protein bias, showing distinct biological effects compared to the natural ligand.
DOI 10.1021/acs.jmedchem.6c01079