Asmita Manandhar

Development of Potent G Protein Pathway-Biased GPR183 Agonists

This paper develops potent G protein-biased GPR183 agonists with low nanomolar potency and complete Gi protein bias, showing distinct biological effects compared to the natural ligand.

Multi-Coloured Sequential Resonance Energy Transfer for Simultaneous Ligand Binding at G Protein-Coupled Receptors

The paper develops a method to study simultaneous ligand binding at GPCRs using multi-colored sequential resonance energy transfer and applies it to the FFA1 receptor.

The SH Protein of Mumps Virus is a Druggable Pentameric Viroporin

This study identifies the mumps virus SH protein as a pentameric viroporin and shows it functions as a chloride channel inhibited by BIT225.