BiochemistrybioRxivPreprint
A Multi-Disciplinary Framework for Decoding S1PR1-Selective Agonism
Leiye Yu, Haizhan Jiao, Bin Pang…·Ruobing Ren
The paper reports cryo-EM structures of S1PR1-Gi complexes bound to agonists and identifies molecular features driving selectivity for S1PR1 over S1PR3 and S1PR5.
DOI 10.1101/2025.08.27.672536