Ruobing Ren

This paper identifies metabolic dysregulation caused by abiraterone in prostate cancer patients and develops Lifehug-9892 to suppress tumors while preserving systemic metabolic health.

This study designs high-fidelity CRISPR-Cas variants using a physics-driven approach combining molecular dynamics and protein language models, achieving significant improvements in fidelity with minimal experimental validation.

The paper reports cryo-EM structures of S1PR1-Gi complexes bound to agonists and identifies molecular features driving selectivity for S1PR1 over S1PR3 and S1PR5.