Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at ER monitoring and regulating fatty acids
Song‐iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura, Hiroshi Ohno, Yuki Murayama, Yuichi Aita, Yoshinori Takeuchi, Yoshinori Osaki, , Hitoshi Shimano
The paper shows RHBDL4 cleaves SREBP-1c at the ER, with its activity modulated by fatty acid types, and demonstrates its role in lipid homeostasis.
bioRxiv · Aug 24, 2021 · PreprintMolecular Biology