Hitoshi Shimano

This study introduces ExAPC microscopy for label-free visualization of intracellular structures, showing its ability to resolve biomolecular condensates, lipid droplets, and mitochondria with high spatiotemporal resolution.

This study shows that ASXL1 mutations in mice promote atherosclerosis by dysregulating innate immunity through impaired inhibition of NF-κB signaling.

The paper shows RHBDL4 cleaves SREBP-1c at the ER, with its activity modulated by fatty acid types, and demonstrates its role in lipid homeostasis.

This study introduces iCMM, a method to rapidly manipulate mitochondrial morphology, revealing its rapid impact on biological information reconstitution.