Hege Giercksky Russnes

The paper profiles immune cell composition in sentinel and axillary lymph nodes of breast cancer patients, finding T-cell exhaustion and immune changes associated with metastasis.

The paper introduces CANCAN, a computational framework for analyzing copy number and mutation heterogeneity in DNA sequencing data, showing high concordance with existing methods and improved performance on targeted sequencing data.

The paper identifies copy number motifs in breast cancer genomes that predict disease outcome and driver events, outperforming existing clinical and genomic markers.