Chulin Sha

CLM-X is a multimodal single-cell foundation model that outperforms existing methods in cross-modal translation and perturbation prediction across scRNA-seq and scATAC-seq datasets.

CLM-access is a foundation model for scATAC-seq data that improves batch correction, cell type annotation, and multi-modal integration compared to existing methods.

This study develops STMS to analyze subcellular proteomic changes during cuproptosis, identifies key regulators, and discovers potential inhibitors.

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.