Aaron B. Bowman

This study constructs cell-type-specific gene regulatory networks in Alzheimer's disease using single-nucleus transcriptomics and genotype data, identifying both established and novel regulatory elements.

The paper predicts neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases using a systems biology approach and integrates metabolic networks with single nucleus RNA sequencing data.

This study investigates the role of the JAK2/STAT3 signaling pathway in mitigating methylmercury toxicity in astrocytes, showing that STAT3 inhibition worsens oxidative stress and cell death.

The paper identifies BTBD9 as a novel component of IGF signaling that mitigates manganese-induced dopaminergic dysfunction in multiple species.