Priyanka Baloni

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a-deficient mice

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer's tau pathology and uncover human-specific neuronal vulnerability

This study develops a human neuronal chimera model to study Alzheimer's tau pathology, showing human-specific vulnerability and recapitulating mature AD features in vivo.

Mitochondrial Complex I Modulator Restores Network Resilience in Advanced Alzheimer's Disease Through Metabolic Reprogramming

The paper shows that modulating mitochondrial complex I in advanced Alzheimer's disease improves metabolic resilience through coordinated mitochondrial and lipid metabolism.

Mitochondrial bioenergetic signatures differentiate asymptomatic from symptomatic Alzheimer's disease

The paper identifies preserved mitochondrial bioenergetics in asymptomatic Alzheimer's disease brains and suggests NAD+ precursor interventions could maintain cognitive function despite pathology.

Neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases predicted via a systems biology-based approach

The paper predicts neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases using a systems biology approach and integrates metabolic networks with single nucleus RNA sequencing data.

Ndufs4 knockout induces transcriptomic signatures of Alzheimer's Diseases that are partially reversed by mitochondrial complex I inhibitor

This study shows that reducing mitochondrial complex I activity in mice induces AD-like transcriptomic changes, which are partially reversed by a complex I inhibitor.

Understanding disease-associated metabolic changes in human colon epithelial cells using iColonEpithelium metabolic reconstruction

The paper develops a cell-type-specific genome-scale metabolic model of human colonic epithelial cells to identify metabolic signatures associated with inflammatory bowel disease.

APOE Genotype and Biological Age Impact Inter-Omic Associations Related to Bioenergetics

The paper identifies APOE genotype-related metabolite associations with biological age and bioenergetics in humans, showing counterintuitive patterns in {varepsilon}2 and {varepsilon}4 carriers.

A Genome Scale Transcriptional Regulatory Model of the Human Placenta

The paper constructs a genome-scale transcriptional regulatory network of the human placenta using genomic and transcriptomic data, identifying key regulators of preterm birth.

Genome-microbiome interplay provides insight into the determinants of the human blood metabolome

The paper analyzes the genetic and microbiome contributions to blood metabolite variation across 2,049 individuals, finding that over 60% of metabolites are associated with either genetics or the microbiome, with some showing interaction effects.

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

The paper compares microglial transcriptomic responses to Aβ peptide aggregates ex vivo and in vivo, finding distinct responses and highlighting the limitations of using ex vivo models to predict in vivo behavior.

Identifying differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease using metabolic networks of human brain regions

The paper identifies differences in bile acid pathways for cholesterol clearance in Alzheimer’s disease by analyzing transcriptomes and metabolomics data from brain samples.