Junkai Xie

This study constructs cell-type-specific gene regulatory networks in Alzheimer's disease using single-nucleus transcriptomics and genotype data, identifying both established and novel regulatory elements.

The paper predicts neuronal subtype-specific metabolic changes in neurodegenerative and neuropsychiatric diseases using a systems biology approach and integrates metabolic networks with single nucleus RNA sequencing data.

This study identifies Kir7.1's role in maintaining membrane potential and directional sensing during neutrophil chemotaxis, showing its necessity for polarized depolarization and chemotactic movement.

The paper investigates how nucleosome positioning elements and pre-assembled chromatin states affect transgene expression and retention, finding that nucleosome positioning has a greater impact than hyperacetylated chromatin states.

This study shows that low-dose lead exposure alters heterochromatin marks in SH-SY5Y cells, with some changes persisting through differentiation and affecting neuronal morphology.