Fábio Madeira

R2DT is a software platform for visualizing RNA secondary structures with enhanced features like SNP display and template-free visualization.

The paper reannotates ligand binding sites in UniProtKB using ChEBI identifiers and improves search facilities for these annotations.

R2DT generates standardised 2D RNA structure diagrams for diverse ncRNA types using a template library, producing a large dataset of visualisations.

The paper identifies functionally important protein residues by analyzing missense variant distribution across human protein domains and finds these residues are enriched in disease-associated variants.