Stuart A. MacGowan

Slivka and Slivka-bio provide a lightweight framework for deploying bioinformatics tools as web services, enabling easy execution of code via HTTP and demonstrating with 15+ protein and RNA analysis tools.

This study determines the structural morphology and formation of the human exocyst complex, revealing an extended architecture with minimal intersubunit interaction and a single nucleation site.

The paper investigates how ACE2 missense variants affect SARS-CoV-2 Spike binding, identifying variants that enhance or inhibit binding and their potential impact on infection risk.

The paper analyzes human population variants in ankyrin repeats using structural and evolutionary data to identify functionally important sites.

The paper predicts ACE2 missense variants that enhance or inhibit SARS-CoV-2 Spike binding, identifies protective and susceptibility variants, and suggests their implications for COVID-19 risk and therapeutic design.

The paper identifies functionally important protein residues by analyzing missense variant distribution across human protein domains and finds these residues are enriched in disease-associated variants.