Loren Dean Williams

The paper reconstructs evolutionary rate trajectories of 528 genes from the Last Bacterial Common Ancestor across 2.1 billion years, identifying four clusters with distinct patterns linked to gene function and environmental changes.

R2DT is a software platform for visualizing RNA secondary structures with enhanced features like SNP display and template-free visualization.

The paper identifies BEAN and HABAS domains in bacterial RNA polymerase subunits, showing their evolutionary divergence and phylogenetic distribution.

This paper demonstrates the directed evolution of the Saccharomyces cerevisiae mitochondrial translation system as an orthogonal system to the cytosolic TS, revealing functional dependencies and enabling translation engineering.

R2DT generates standardised 2D RNA structure diagrams for diverse ncRNA types using a template library, producing a large dataset of visualisations.

The paper demonstrates that Fe2+ cleaves RNA via a non-oxidative in-line mechanism, is more reactive than Mg2+, and is stably associated with ribosomes under anaerobic conditions.