Fabrice Duprat

The paper examines astrocyte remodeling in a Scn1a+/− mouse model of Dravet Syndrome, finding long-lasting changes in GFAP expression, astrocyte network expansion, and impaired hemichannel function.

The paper introduces an open-source Python package for automated video acquisition and semi-automated detection of convulsive seizures in rodents with high accuracy.

This study identifies a neocortex-specific mechanism of cortical spreading depression (CSD) initiated by hyperactivity of GABAergic neurons and NaV1.1 channel gain-of-function, linking it to Familial Hemiplegic Migraine type-3.