Top-down control of the descending pain modulatory system drives placebo analgesia
Giulia Livrizzi, Jingzhu Liao, Desiree A. Johnson…·Matthew R. Banghart
This study identifies the neural circuits underlying placebo analgesia, showing that cortical control of the descending pain modulatory system (DPMS) drives pain suppression through endogenous opioid signaling in the periaqueductal gray.