Jean C. Yung

Inputs to the locus coeruleus from the periaqueductal gray and rostroventral medulla shape opioid-mediated descending pain modulation

The paper identifies novel synaptic pathways from the periaqueductal gray and rostroventral medulla to the locus coeruleus that drive opioid-mediated antinociception.

In vivo photopharmacology with light-activated opioid drugs

This paper introduces photoactivatable opioid drugs for in vivo photopharmacology, enabling rapid, localized manipulation of opioid receptors and associated behaviors.

In vivo photopharmacology with a caged mu opioid receptor agonist drives rapid changes in behavior

The paper develops a caged mu opioid receptor agonist that, when photoactivated, rapidly increases locomotion in mice.