This study identifies small-molecule inhibitors of BK polyomavirus infection through phenotypic screening, revealing compounds with distinct antiviral mechanisms and cellular effects.

bioRxiv · Aug 20, 2026 · PreprintMicrobiology

Chromosome-associated spot formation by human cytomegalovirus immediate early 1 (IE1) protein

Mamata Savanagouder, Tejasv Gupta, Martin Messerle, Eva Maria Borst, Thomas Friedrich Schulz, Divya Das, Emma L. Poole, John H. Sinclair, Wojciech Zdanowski, Tomasz Waśniewski, Marek Zygmunt, Sławomir Wołczyński, Magdalena Weidner-Glunde

This study identifies a novel mitotic localization pattern of HCMV IE1 protein called chromosome-associated spots (CAS) in leukemia and glioblastoma cells, suggesting a new cell-type specific function.

bioRxiv · Dec 18, 2025 · PreprintMicrobiology

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits

Lennart Riemann, Rodrigo Gutiérrez, Ivan Odak, Joana Barros‐Martins, Lennart Matthias Roesner, Ximena León-Lara, Christine Susanne Falk, Thomas Friedrich Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

The paper profiles the immune system of elderly individuals and identifies systems-level signatures of aging, sex, smoking, and clinical traits using high-dimensional flow cytometry and multi-block analysis.

EBioMedicine · Jan 24, 2025Peer-reviewedImmunology

Evaluating assembly and variant calling software for strain-resolved analysis of large DNA-viruses

Zhi-Luo Deng, Akshay Dhingra, Adrian Fritz, Jasper Götting, Philipp C. Münch, Lars Steinbrück, Thomas Friedrich Schulz, Tina Ganzenmueller, Alice Carolyn McHardy

This study benchmarks assemblers and variant callers for strain-resolved analysis of large DNA viruses, identifying best practices and challenges in handling low-divergent viral populations.

Briefings in Bioinformatics · May 24, 2020Peer-reviewedBioinformatics