Thomas Werfel

Multi-omic triangulation identifies molecular candidates of atopic dermatitis severity

This study identifies 440 genes/proteins associated with atopic dermatitis severity through multi-omics analyses and highlights four with significant cross-evidence, including CEP85, which may contribute to severity via impaired phagocytosis.

Different CMV-specific effector T cell subtypes are associated with age, CMV serostatus, and increased systolic blood pressure

The paper examines the association between CMV-specific effector T cell subtypes, age, CMV serostatus, and systolic blood pressure in an elderly cohort.

The deubiquitinating enzyme CYLD impairs NF-κB- and STAT1-dependent macrophage intrinsic immunity to Staphylococcus aureus

This study shows that CYLD impairs macrophage immunity to S. aureus by inhibiting STAT1 and NF-κB pathways, contributing to disease severity in atopic dermatitis.

Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits

The paper profiles the immune system of elderly individuals and identifies systems-level signatures of aging, sex, smoking, and clinical traits using high-dimensional flow cytometry and multi-block analysis.