Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan C. Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A. Fon, Elena De Cecco, Adriano Aguzzi
The paper uses CRISPR screens to identify OXR1 and EMC4 as modifiers of α-synuclein aggregation in Parkinson's disease and related synucleinopathies.
bioRxiv · Jun 10, 2025 · PreprintNeuroscience