Vangelis Bouris

PODXL regulates the neuronal entry of α-synuclein aggregates

This study identifies PODXL as a suppressor of α-synuclein fibril uptake in neurons, highlighting its glycan-dependent surface properties and interaction with MME.

Prion propagation is controlled by a hierarchical network involving the nuclear Tfap2c and hnRNP K factors and the cytosolic mTORC1 complex

The paper identifies TFAP2C as a genetic interactor of hnRNP K, showing their roles in mTOR metabolic regulation and a causal link to prion propagation.

Genome-wide arrayed CRISPR activation screen for prion protein modulators

The paper performs a genome-wide CRISPR activation screen to identify genes modulating PrPC abundance, finding 531 genes with significant effects and validating 45 of them.

Control of Prion Uptake by Bone Morphogenetic Protein Signaling

The paper identifies BMP signaling as a regulator of prion uptake by screening for genetic modifiers in human cells and shows that modulating BMP components affects prion internalization.

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation

The paper uses CRISPR screens to identify OXR1 and EMC4 as modifiers of α-synuclein aggregation in Parkinson's disease and related synucleinopathies.

Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing

The paper constructs genome-wide CRISPR libraries for gene ablation, activation, and silencing with high efficacy and reports novel gene regulators and modifiers.