PODXL regulates the neuronal entry of α-synuclein aggregates
Sandesh Neupane, Lea Šustić, Lorenzo Maraio, Vangelis Bouris, Giovanni Mariutti, Rafaela Ribeiro, Jiang-An Yin, Ronald Melki, Giuseppe Legname, Elena De Cecco, Adriano Aguzzi
This study identifies PODXL as a suppressor of α-synuclein fibril uptake in neurons, highlighting its glycan-dependent surface properties and interaction with MME.
bioRxiv · Oct 21, 2026 · PreprintNeuroscience