Author

Thomas Goiran

Montreal Neurological Institute and HospitalORCID 0000-0001-5838-8798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Edward A. FoniD· 3 shared Nathan C. KarpilovskyiD· 3 shared Esther del Cid‐PelliteroiD· 2 shared Jace Jones-TabahiD· 2 shared Thomas M. DurcaniD· 2 shared Wen LuoiD· 2 shared Adriano AguzziiD· 1 shared Alla TimofeevaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersNeuroscience

Edward A. FonORCID

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3 papers

Recent·Most cited

Molecular BiologyNeurobiology of DiseasePeer-reviewedJun 11, 2026

N-terminal acetylation reduces α-synuclein pathology in models of Parkinson's disease

Esther del Cid‐Pellitero, Thomas Goiran, Zaid A.M. Al‐Azzawi…·Edward A. Fon

This study shows that N-terminal acetylation of α-synuclein reduces aggregation, uptake, seeding, and toxicity in Parkinson's disease models.

1 citation

mouseproteomics

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NeurosciencebioRxivPreprintJun 10, 2025

Large-scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation

Sandesh Neupane, Lea Nikolić, Lorenzo Maraio…·Adriano Aguzzi

The paper uses CRISPR screens to identify OXR1 and EMC4 as modifiers of α-synuclein aggregation in Parkinson's disease and related synucleinopathies.

2 citations

humanCRISPR screen

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NeuroscienceMolecular NeurodegenerationPeer-reviewedNov 24, 2024

The Parkinson's disease risk gene cathepsin B promotes fibrillar alpha-synuclein clearance, lysosomal function and glucocerebrosidase activity in dopaminergic neurons

Jace Jones-Tabah, Kathy He, Nathan C. Karpilovsky…·Edward A. Fon

This study investigates the role of cathepsin B in Parkinson's disease by analyzing genetic variants and manipulating catB function in cell models to assess its impact on lysosomal activity and alpha-synuclein clearance.

53 citationstop 1%

humanbulk RNA-seq

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