Author

Andrea D. Thompson

University of MichiganORCID 0000-0001-8798-2024Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 2 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Adam S. HelmsiD· 2 shared Jaime M. YobiD· 2 shared Jodie InglesiD· 2 shared Sharlene M. DayiD· 2 shared Alexandre C. PereiraiD· 1 shared Anamika Kannan· 1 shared Carolyn Yung HoiD· 1 shared Chelsea Pankiewicz· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Adam S. HelmsORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintJul 21, 2026

Pathogenic MYBPC3 missense variants alter protein-protein interactions within the sarcomere

Andrea D. Thompson, Chelsea Pankiewicz, Lucy Plenge…·Sharlene M. Day

This study identifies pathogenic MYBPC3 missense variants in HCM patients and shows they disrupt protein interactions and alter proximity to thin-filament proteins.

DOI 10.64898/2026.05.27.727676

humanproteomics

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GeneticsGenetics in MedicinePeer-reviewedMar 29, 2021

Computational prediction of protein subdomain stability in MYBPC3 enables clinical risk stratification in hypertrophic cardiomyopathy and enhances variant interpretation.

Andrea D. Thompson, Adam S. Helms, Anamika Kannan…·SHaRe investigators

The paper uses STRUM to predict subdomain stability in MYBPC3 variants, showing that variants causing misfolding are associated with higher adverse event rates in HCM patients.

16 citations

humanprotein structure

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