Jaime M. Yob

This study identifies pathogenic MYBPC3 missense variants in HCM patients and shows they disrupt protein interactions and alter proximity to thin-filament proteins.

This study uses human living myocardial slices to examine how sodium glucose co-transporter inhibitors affect myocardial work in hypertrophic cardiomyopathy under varying loading conditions.

This study identifies differentially expressed lncRNAs in a mouse HCM model and prioritizes them using cross-species conservation and micropeptide coding potential.

The paper uses STRUM to predict subdomain stability in MYBPC3 variants, showing that variants causing misfolding are associated with higher adverse event rates in HCM patients.