Daiana A. Capdevila

The paper investigates how allostery evolves in the ArsR superfamily by showing that functional diversification arises from internal dynamics rather than large conformational changes.

The paper uses sequence similarity networks and structural analysis to explore functional diversity in bacterial metalloregulator families, identifying conserved features and functional subgroups.

This paper evolves DNA operators to enhance protein-DNA interactions for better transcriptional control in cell-free systems.

This paper develops a highly sensitive lateral flow assay for detecting metal contaminants, achieving regulatory limits for lead in environmental samples.

The paper introduces a cell-free biosensor signal amplification circuit called polymerase strand recycling (PSR) that enhances biosensor sensitivity for small molecule detection.

A cell-free platform pairing T7 RNA polymerase, allosteric transcription factors and DNA templates yields fluorescent RNA output to detect antibiotics, small molecules and metals in water.