Leandra M. Brettner

The paper uses single-cell RNA sequencing to analyze stress responses in yeast, finding that stressed cells show more variability than unstressed cells and that population-level analyses can obscure individual differences.

INgen enables DNA amplification within fixed cells, overcoming limitations in single-cell genomics by allowing sequencing without physical cell isolation.

This paper examines single-cell ribosome content variation in two microbes, finding it does not correlate with growth rate or nutrient availability, challenging the growth law concept.

This paper introduces a high-throughput single-cell RNA-seq platform for yeasts that enables multiplexing of hundreds of strains and environments, revealing transcriptional heterogeneity within clonal populations.

The paper engineers a synthetic developmental gene network in E. coli that couples stochastic differentiation with programmed cell death to enable cooperative cellulose utilization, but also observes cheater phenotypes and models evolutionary escape.