Author

Charles A. Steward

Wellcome Sanger InstituteORCID 0000-0001-8829-5349Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Adam FrankishiD· 2 shared Jennifer HarrowiD· 2 shared Mark DiekhansiD· 2 shared Paul FlicekiD· 2 shared Ahmed Abdel‐LatifiD· 1 shared Alba Sanchis‐JuaniD· 1 shared Alethia Dixon· 1 shared Anand Singh· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersGenomics

Adam FrankishORCID

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3 papers

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintOct 1, 2026

Sotagliflozin Reprograms Hepatic Lipid Metabolism and Attenuates Atherosclerosis Beyond Empagliflozin in CKM Mice

Keith Louis Saum, Jessica Sim, Lixia Zeng…·Subramaniam Pennathur

This study compares sotagliflozin and empagliflozin in CKM mice, finding sotagliflozin more effectively reduces atherosclerosis and metabolic syndrome through hepatic lipid metabolism reprogramming.

DOI 10.64898/2026.09.25.754502

mousebulk RNA-seq

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GenomicsbioRxivPreprintMay 30, 2019

Systematic re-annotation of 191 genes associated with early-onset epilepsy unmasks de novo variants linked to Dravet syndrome in novel SCN1A exons

Charles A. Steward, Jolien Roovers, Marie‐Marthe Suner…·Adam Frankish

The paper updates gene annotations for 191 epilepsy genes, reclassifying variants and identifying new de novo SCN1A variants in Dravet syndrome patients.

DOI 10.1101/648576

humanbulk RNA-seq

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GenomicsbioRxivPreprintFeb 12, 2018

Multiple laboratory mouse reference genomes define strain specific haplotypes and novel functional loci

Jingtao Lilue, Anthony Doran, Ian T. Fiddes…·Thomas Keane

The paper presents full-length de novo genome assemblies for 16 inbred mouse strains, identifying strain-specific haplotypes and novel functional loci, including a large unannotated gene with potential developmental roles.

10 citations

mousewhole-genome sequencing

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