Subramaniam Pennathur

This study compares sotagliflozin and empagliflozin in CKM mice, finding sotagliflozin more effectively reduces atherosclerosis and metabolic syndrome through hepatic lipid metabolism reprogramming.

This study shows that accelerated citrate production by osteocytes in CKD mice protects kidney function, suggesting citrate handling as a therapeutic target.

This study shows dapagliflozin reduces hypoxia-induced metabolic stress, cell death, and fibrosis in kidney organoids derived from human pluripotent stem cells.

The paper predicts destabilizing tyrosine phosphorylations in cancers using machine learning, finding 58% of recurrent phosphorylations are destabilizing and identifying pathway and network patterns associated with these events.

This study identifies PPAR-dependent mitochondrial programming as a limiting factor in the differentiation of human stem cell-derived β cells and shows that PPAR agonists can enhance β cell formation and function.