Ahmed Abdel‐Latif

Sotagliflozin Reprograms Hepatic Lipid Metabolism and Attenuates Atherosclerosis Beyond Empagliflozin in CKM Mice

This study compares sotagliflozin and empagliflozin in CKM mice, finding sotagliflozin more effectively reduces atherosclerosis and metabolic syndrome through hepatic lipid metabolism reprogramming.

Autotaxin Inhibition Ameliorates HFpEF Phenotype By Reducing LPA-Mediated Systemic Inflammation And Cardiac Remodeling

This study shows autotaxin inhibition reduces LPA-mediated inflammation and cardiac remodeling in HFpEF, improving diastolic function and fibrosis in mice and showing altered lysophospholipid profiles in humans.

Soluble Urokinase Plasminogen Activator Receptor Primes Macrophages and Worsens Heart Failure with Preserved Ejection Fraction

This paper shows that elevated suPAR worsens HFpEF by priming macrophages and amplifying inflammatory responses, identifying a therapeutic target for anti-suPAR antibodies.

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEF

This study shows that sotagliflozin improves diastolic dysfunction in HFpEF by enhancing lipid metabolism and reducing inflammation.

Comparative Analysis of Housing Temperature Impact on Heart Failure with Preserved Ejection Fraction in J vs N Strain C57BL/6 Mice

This study examines how mouse strain and housing temperature affect metabolic syndrome and HFpEF development in a two-hit model, finding strain-specific responses to thermoneutral conditions.

Inherent Metabolic Adaptations in Adult Spiny Mouse (Acomys) Cardiomyocytes Facilitate Enhanced Cardiac Recovery Following Myocardial Infarction

This study identifies unique metabolic adaptations in Acomys cardiomyocytes that enhance cardiac recovery after myocardial infarction compared to Mus musculus.

Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction

This study shows that spiny mice (Acomys) have better cardiac recovery after myocardial infarction compared to common lab mice, with less scarring and better function.