Systems BiologybioRxivPreprint
Electrophile scanning by chemical proteomics reveals a potent pan-active DUB probe for investigation of deubiquitinase activity in live cells
Daniel Conole, Fangyuan Cao, Christopher W. am Ende…·Edward W. Tate
The paper identifies a small molecule DUB probe, IMP-2373, that quantitatively engages multiple DUBs in live cells and demonstrates its use in studying DUB activity changes during MYC deregulation.
DOI 10.1101/2022.09.28.509970