Liang Xue

MSstatsResponse improves detection of drug-protein interactions in chemoproteomics by using a semi-parametric statistical model that avoids fixed curve shapes, enhancing accuracy and robustness in low-replicate and low-dose settings.

CoSpred is a machine learning workflow that predicts complete tandem mass spectra from peptide sequences, improving spectral library matching by including non-backbone ions.

The paper identifies a small molecule DUB probe, IMP-2373, that quantitatively engages multiple DUBs in live cells and demonstrates its use in studying DUB activity changes during MYC deregulation.