Qirun Wang

The paper uses spatial transcriptomics and single-nucleus RNA sequencing to analyze dorsoventral molecular organization in hippocampus and medial entorhinal cortex across five species, identifying conserved and species-specific patterns.

This paper designs AAV vectors with enhancer-controlled ITR promoters to improve payload capacity and enable tissue-specific gene editing with a single AAV.

The paper develops a theory integrating physical constraints and biological regulations to explain universal osmoresponses in microorganisms, predicting growth thresholds and growth rate changes under osmotic stress.

The paper proposes a mechanistic model of mRNA buffering that couples transcription, exportation, and degradation, explaining constant mRNA concentrations under various perturbations.

This paper develops a theoretical framework for protein synthesis that explains the growth law, showing it is universal under similar environments but non-universal when environments differ significantly.

The paper shows that nonlinear scaling of gene expression with cell volume arises from heterogeneous promoter recruitment abilities to RNA polymerases, supported by analysis of yeast promoter sequences.