Luzi Yang

AAV vectors with enhancer-controlled ITR promoters

This paper designs AAV vectors with enhancer-controlled ITR promoters to improve payload capacity and enable tissue-specific gene editing with a single AAV.

A Drug-Elicitable Alternative-Splicing Module (DreAM) for Tunable AAV Expression and Controlled Myocardial Regeneration

An all-in-one AAV vector for cardiac-specific gene silencing by an adenine base editor

This study shows that single-AAV delivery of base editors can achieve effective cardiac gene silencing with higher success rates than dual-AAV systems.

Myocardial infarction creates a critical time window for AAV gene therapy

This paper shows that myocardial infarction creates a time window where AAV gene therapy is more effective in mice, improving gene expression and therapeutic outcomes when administered three days post-infarction.

In vivo proximity proteomics uncovers palmdelphin (PALMD) as a Z-line-associated mitigator of isoproterenol-induced cardiac injury

This study identifies PALMD as a Z-line-associated protein that mitigates cardiac injury through stabilization of NEXN using in vivo proximity proteomics.