Author

Jithu Krishna

University of Massachusetts AmherstORCID 0000-0001-8875-7566Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Ryan Hung-Hsun LuiD· 1 shared S. ThayumanavaniD· 1 shared Yasin Alp· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

3 top collaborators · 3 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Ryan Hung-Hsun LuORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Cancer BiologyJournal of the American Chemical SocietyPeer-reviewedJan 2, 2026

Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors

Ryan Hung-Hsun Lu, Jithu Krishna, Yasin Alp, S. Thayumanavan

This paper introduces PolyTACs, a polymer-antibody conjugate platform for extracellular protein degradation without lysosome-targeting receptors, demonstrating efficacy against three membrane proteins and soluble targets.

17 citationstop 1%

experimental assaydrug response / drug discovery