S. Thayumanavan

Enzyme Activation of Triggerable Polymeric Lysosome Targeting Chimeras

This paper introduces tPolyTACs, a covalent enzyme-responsive platform for extracellular protein degradation, showing enhanced selectivity and efficiency by using phosphatase-cleavable substrates to trigger lysosomal targeting.

Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting Receptors

This paper introduces PolyTACs, a polymer-antibody conjugate platform for extracellular protein degradation without lysosome-targeting receptors, demonstrating efficacy against three membrane proteins and soluble targets.

Multivalent Ligand-Protein Interactions Using Polymeric Lysosome-Targeting Chimeras (PolyTACs) Leads to Lysosome-Targeting Receptor-Independent Degradation of Transmembrane Proteins

The paper demonstrates that multivalent ligand-protein interactions using PolyTACs can degrade transmembrane proteins without lysosome-targeting receptors.