Mafalda Galhardo

This study identifies a dual-phase enhancer that maintains pancreatic progenitor cells and stabilizes lineage identity, preventing pathological plasticity and disease.

The paper shows that an ATTTC repeat insertion in an Alu element enhances a DAB1 enhancer, leading to neuronal dysfunction in SCA37.

This study shows FOXM1 reverts aging chromatin profiles by repressing AP-1, a senescence-associated pioneer factor, in human fibroblasts.

This study shows a small-molecule agonist of KIF2C enhances DNA repair and mitigates aging phenotypes in progeria and Down syndrome models.

The paper identifies cis-regulatory elements in the zebrafish and human pancreas, revealing disease-related enhancers that affect gene expression and contribute to pancreatic disorders.