Stem cell differentiation is a stochastic process with memory
Patrick S. Stumpf, Rosanna C. G. Smith, Michael Lenz, Andreas Schuppert, Franz-Josef Müller, Ann C. Babtie, Thalia E. Chan, Michael P.H. Stumpf, Colin P. Please, Sam Howison, Fumio Arai, Ben D. MacArthur
This study shows that stem cell differentiation involves stochastic transitions through hidden microstates, revealing epigenetic memory and a statistical mechanics framework for cellular identity.
Cell Systems · Sep 1, 2017Peer-reviewedSystems Biology