Author

Michael Lenz

Maastricht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Systems Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:deconvolution· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

André EsseriD· 1 shared Andreas SchuppertiD· 1 shared Ann C. BabtieiD· 1 shared Ben D. MacArthuriD· 1 shared Carina Birkhofer· 1 shared Colin P. PleaseiD· 1 shared Franz-Josef Müller· 1 shared Fumio AraiiD· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperMolecular Biology

André EsserORCID

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3 papers

Recent·Most cited

Adipose tissue in health and disease through the lens of its building blocks

Michael Lenz, Ilja C.W. Arts, Ralf Peeters, Theo M. C. M. de Kok, Gökhan Ertaylan

The paper presents a framework for identifying cellular heterogeneity and markers in adipose tissue using transcriptomics, validated with an independent dataset and analyzing 779 samples across multiple conditions.

Scientific Reports · Jun 26, 2020Peer-reviewedSystems Biology

Leukocyte counts based on site-specific DNA methylation analysis

Joana Frobel, Tanja Božić, Michael Lenz, Peter Uciechowski, Yang Han, Reinhild Herwartz, Klaus Strathmann, Susanne Isfort, Jens Panse, André Esser, Carina Birkhofer, Uwe Gerstenmaier, Thomas Kraus, Lothar Rink, Steffen Koschmieder, Wolfgang Wagner

The paper develops a method to estimate leukocyte counts using DNA methylation analysis, achieving similar precision to conventional methods with advantages in sample handling.

Clinical Chemistry · Nov 8, 2017Peer-reviewedMolecular Biology

Stem cell differentiation is a stochastic process with memory

Patrick S. Stumpf, Rosanna C. G. Smith, Michael Lenz, Andreas Schuppert, Franz-Josef Müller, Ann C. Babtie, Thalia E. Chan, Michael P.H. Stumpf, Colin P. Please, Sam Howison, Fumio Arai, Ben D. MacArthur

This study shows that stem cell differentiation involves stochastic transitions through hidden microstates, revealing epigenetic memory and a statistical mechanics framework for cellular identity.

Cell Systems · Sep 1, 2017Peer-reviewedSystems Biology