Fumio Arai

The paper identifies CXCL16 macrophages in bone metastases that transiently restrain cancer growth and G-CSF niches that promote reactivation, revealing CAF-bone-marrow interactions as a therapeutic target.

This paper uses transfer learning to map biology from mouse to human bone marrow using single-cell RNA-sequencing data, showing improved accuracy with retraining and zero-shot learning.

This study uses single-cell profiling and deep learning to show that hematopoietic stem cell self-renewal declines with age due to stochastic division patterns and prior division history.

This study shows that stem cell differentiation involves stochastic transitions through hidden microstates, revealing epigenetic memory and a statistical mechanics framework for cellular identity.