Author

Rosanna C. G. Smith

University of SouthamptonORCID 0000-0002-4058-1263Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Ben D. MacArthuriD· 2 shared Fumio AraiiD· 2 shared Patrick S. StumpfiD· 2 shared Andreas SchuppertiD· 1 shared Ann C. BabtieiD· 1 shared Colin P. PleaseiD· 1 shared Franz-Josef Müller· 1 shared Haruka Imanishi· 1 shared

Activity by Year

2017-2025 · peak 1/yr

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10 top collaborators · 33 mutual co-author links

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2 shared papersSystems Biology

Ben D. MacArthurORCID

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3 papers

Recent·Most cited

FGF and MafB regulated cadherin expression drives lamina formation in the auditory hindbrain

Rosanna C. G. Smith, Maryam Clark, Mireya Vazquez-Prada, Marc Astick, Kristina C Tubby, Stephen Robert Price

This study identifies a signaling cascade involving FGF8, MafB, and cadherin-22 that drives lamina formation in the auditory hindbrain of birds.

bioRxiv · Apr 30, 2025 · PreprintDevelopmental Biology

Mapping biology from mouse to man using transfer learning

Patrick S. Stumpf, Xin Du, Haruka Imanishi, Yuya Kunisaki, Yuichiro Semba, Timothy J. Noble, Rosanna C. G. Smith, Matthew J.J. Rose-Zerilli, Jonathan J. West, Richard O. C. Oreffo, Mahesan Niranjan, Koichi Akashi, Fumio Arai, Ben D. MacArthur

This paper uses transfer learning to map biology from mouse to human bone marrow using single-cell RNA-sequencing data, showing improved accuracy with retraining and zero-shot learning.

bioRxiv · Dec 26, 2019 · PreprintSystems Biology

Stem cell differentiation is a stochastic process with memory

Patrick S. Stumpf, Rosanna C. G. Smith, Michael Lenz, Andreas Schuppert, Franz-Josef Müller, Ann C. Babtie, Thalia E. Chan, Michael P.H. Stumpf, Colin P. Please, Sam Howison, Fumio Arai, Ben D. MacArthur

This study shows that stem cell differentiation involves stochastic transitions through hidden microstates, revealing epigenetic memory and a statistical mechanics framework for cellular identity.

Cell Systems · Sep 1, 2017Peer-reviewedSystems Biology