Author

Patricio Fernández‐Silva

Consejo Superior de Investigaciones CientíficasORCID 0000-0001-8971-7355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Adrián Velázquez‐CampoyiD· 1 shared Aleksandra TrifunovićiD· 1 shared Anil Sukru Dogan· 1 shared Anup MishraiD· 1 shared Aurelio ReyesiD· 1 shared Bertil MacaoiD· 1 shared Bradley PeteriD· 1 shared Carlo Fiore ViscomiiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBiochemistry

Adrián Velázquez‐CampoyORCID

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2 papers

Recent·Most cited

Functional plasticity of AIF revealed by dimerization and CHCHD4 interaction states

Olga Soriano, Soraya Hernández-Hatibi, Rebeca Gracia-Domingo, Silvia Romero-Tamayo, Miguel Ferrer, Adrián Velázquez‐Campoy, Joaquín Marco-Brualla, Patricio Fernández‐Silva, Santos A. Susín, Milagros Medina, Raquel Moreno‐Loshuertos, Patrícia Ferreira

This study investigates the functional plasticity of AIF through dimerization and CHCHD4 interaction states, revealing conformational dynamics and redox regulation.

bioRxiv · Sep 1, 2026 · PreprintBiochemistry

In vivo and in vitro mechanistic characterization of a clinically relevant PolγA mutation

Pedro Silva-Pinheiro, Carlos Pardo-Hernández, Aurelio Reyes, Lisa Tilokani, Anup Mishra, Raffaele Cerutti, Shuaifeng Li, Dieu Hien Ho, Sebastian Valenzuela, Anil Sukru Dogan, Bradley Peter, Patricio Fernández‐Silva, Aleksandra Trifunović, Julien Prudent, Michal A. Minczuk, , Carlo Fiore Viscomi

This study characterizes the molecular pathogenesis of a POLG mutation by showing how it impairs POLγA function and leads to mtDNA instability through LONP1-dependent degradation.

bioRxiv · Sep 10, 2020 · PreprintGenetics