Author

Han Gia Nguyen

Kanazawa UniversityORCID 0000-0001-8974-9365Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Assay:multiome· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Kien Xuan NgoiD· 2 shared Ngan Thi Phuong LeiD· 2 shared Rémi VuillemotiD· 2 shared Sergei GrudininiD· 2 shared Takashi SumikamaiD· 2 shared Taro Q.P. UyedaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

Kien Xuan NgoORCID

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2 papers

Recent·Most cited

BiophysicsNano LettersPeer-reviewedFeb 25, 2026

SimHS-AFMfit-MD: An Integrative Approach to Deciphering Alpha-Actinin Atomic Conformational Dynamics

Kien Xuan Ngo, Takashi Sumikama, Rémi Vuillemot…·Sergei Grudinin

This paper introduces SimHS-AFMfit-MD, a framework combining HS-AFM, MD simulations, and AFMfit to reconstruct atomic-scale conformational dynamics of alpha-actinin.

5 citations

cryo-EMmultiome

𝕏 PostBluesky

BiophysicsbioRxivPreprintNov 16, 2025

Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments

Kien Xuan Ngo, Takashi Sumikama, Taro Q.P. Uyeda…·Sergei Grudinin

This study investigates how alpha-actinin stabilizes actin filament structure, preventing cofilin-induced helical shortening and cooperative binding.

1 citation

structural biologybiophysical modeling

𝕏 PostBluesky