Takashi Sumikama

This study uses HS-AFM to directly observe conformational changes in FGFR1 during signal transduction, showing that autophosphorylation enables dynamic interactions with FRS2.

This paper introduces Opto-MDMi, a dual-lock optogenetic system that activates endogenous p53 with light, while suppressing basal activity in the dark.

This paper introduces SimHS-AFMfit-MD, a framework combining HS-AFM, MD simulations, and AFMfit to reconstruct atomic-scale conformational dynamics of alpha-actinin.

This study shows that CaMKII holoenzymes form worm-like mesoscale clusters under spatial confinement, with activation leading to cluster expansion and a mutant variant forming clusters even without activation.

The paper uses high-speed AFM to show that CaMKII/{beta} heterododecamers form stable structures with adjacent CaMKII{beta} subunits, revealing their structural role.

This study investigates how alpha-actinin stabilizes actin filament structure, preventing cofilin-induced helical shortening and cooperative binding.

This study uses HS-AFM to visualize NTD dynamics of GluA2-γ2, showing dimer splitting and its role in synaptic clustering.

The paper uses high-speed atomic force microscopy to study activity-dependent structural dynamics of CaMKII in rat, hydra, and C. elegans, revealing species-specific structural changes and phosphatase tolerance in rat CaMKII.

This paper introduces a rapid method to classify heterochromatin and euchromatin using Hi-C data, providing intuitive visual interpretation of contact frequencies.