Author

Ngan Thi Phuong Le

Kanazawa UniversityORCID 0009-0006-1436-1140Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:database / resource· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:imaging· 1

Frequent Co-Authors

Kien Xuan NgoiD· 3 shared Han Gia NguyeniD· 2 shared Rémi VuillemotiD· 2 shared Sergei GrudininiD· 2 shared Takashi SumikamaiD· 2 shared Hoang Duc NguyeniD· 1 shared Ngoc Quoc LyiD· 1 shared Taro Q.P. UyedaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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3 shared papersBiophysics

Kien Xuan NgoORCID

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3 papers

Recent·Most cited

BiophysicsNano LettersPeer-reviewedFeb 25, 2026

SimHS-AFMfit-MD: An Integrative Approach to Deciphering Alpha-Actinin Atomic Conformational Dynamics

Kien Xuan Ngo, Takashi Sumikama, Rémi Vuillemot…·Sergei Grudinin

This paper introduces SimHS-AFMfit-MD, a framework combining HS-AFM, MD simulations, and AFMfit to reconstruct atomic-scale conformational dynamics of alpha-actinin.

5 citations

cryo-EMmultiome

𝕏 PostBluesky

BiophysicsbioRxivPreprintNov 16, 2025

Structural basis for alpha-actinin inhibition of cooperative cofilin binding to actin filaments

Kien Xuan Ngo, Takashi Sumikama, Taro Q.P. Uyeda…·Sergei Grudinin

This study investigates how alpha-actinin stabilizes actin filament structure, preventing cofilin-induced helical shortening and cooperative binding.

1 citation

structural biologybiophysical modeling

𝕏 PostBluesky

BioinformaticsbioRxivPreprintFeb 26, 2025

AFMnanoSALQ: An Accurate Detection Framework for Semi-Automatic Labeling and Quantitative Analysis of α-Hemolysin Nanopores Using Intensity-Height Cues in HS-AFM Data

Thuyen Vinh Tran Nguyen, Ngoc Quoc Ly, Ngan Thi Phuong Le…·Kien Xuan Ngo

AFMnanoSALQ is a semi-automatic framework for labeling and quantifying α-hemolysin nanopores in HS-AFM data using intensity-height cues, offering fast deployment without training.

1 citation

imagingexperimental assay

𝕏 PostBluesky