Rémi Vuillemot

CryoARC reconstructs atomic-resolution conformational landscapes of protein assemblies from cryo-EM data using evolutionary sequence priors and deep learning.

This paper introduces SimHS-AFMfit-MD, a framework combining HS-AFM, MD simulations, and AFMfit to reconstruct atomic-scale conformational dynamics of alpha-actinin.

This study investigates how alpha-actinin stabilizes actin filament structure, preventing cofilin-induced helical shortening and cooperative binding.

AFMfit fits atomic models to AFM data to infer conformational dynamics of single molecules using fast nonlinear NMA and FFT-based search.

The paper presents a cryo-EM conformational heterogeneity challenge to evaluate and improve methods for analyzing molecular motions in heterogeneous samples.

MDTOMO analyzes continuous conformational variability in cryo-ET subtomograms using MD simulations to generate atomic-scale models and free-energy landscapes.