Pharmacology & ToxicologybioRxivPreprint
Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent
Kai Wang, Tony Ngo, Ekta Khare…·Irina Kufareva
This study compares the conformational dynamics of ACKR3 and CXCR4 using MD simulations and BRET assays, revealing that ACKR3's dynamic behavior leads to activation-proneness and G protein-incompetence.
DOI 10.64898/2026.05.17.725760