Author

Ekta Khare

University of California San DiegoORCID 0009-0002-6958-1619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Approach:mixed model· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Approach:simulation· 1

Frequent Co-Authors

Irina KufarevaiD· 2 shared Suchismita RoyiD· 2 shared Tracy M. HandeliD· 2 shared Christopher T. SchaferiD· 1 shared JULIE A. RESNICKiD· 1 shared Kai WangiD· 1 shared Kirti Kandhwal ChahaliD· 1 shared Rezvan ChitsaziiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPharmacology & Toxicology

Irina KufarevaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent

Kai Wang, Tony Ngo, Ekta Khare, Rezvan Chitsazi, Suchismita Roy, Christopher T. Schafer, Tracy M. Handel, Irina Kufareva

This study compares the conformational dynamics of ACKR3 and CXCR4 using MD simulations and BRET assays, revealing that ACKR3's dynamic behavior leads to activation-proneness and G protein-incompetence.

bioRxiv · May 20, 2026 · PreprintPharmacology & Toxicology

Essential strategies for the detection of constitutive and ligand-dependent Gi-directed activity of 7TM receptors using bioluminescence resonance energy transfer

Sofia Endzhievskaya, Kirti Kandhwal Chahal, JULIE A. RESNICK, Ekta Khare, Suchismita Roy, Tracy M. Handel, Irina Kufareva

This study develops and validates BRET-based assays to detect constitutive and ligand-dependent Gi-directed activity in GiPCRs, revealing novel regulatory mechanisms of Smoothened.

bioRxiv · Dec 4, 2024 · PreprintPharmacology & Toxicology