Author

Rezvan Chitsazi

University of California San DiegoORCID 0000-0002-6504-3373Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 2 Research Focus:protein structure prediction· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mixed model· 1

Frequent Co-Authors

Irina KufarevaiD· 3 shared Tracy M. HandeliD· 2 shared Ariane L. JansmaiD· 1 shared Aura F. Celniker· 1 shared Catherina L. SalangaiD· 1 shared Christopher T. SchaferiD· 1 shared Douglas P. DyeriD· 1 shared Ekta KhareiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersPharmacology & Toxicology

Irina KufarevaORCID

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3 papers

Recent·Most cited

Elevated conformational dynamics makes ACKR3 activation-prone and G protein-incompetent

Kai Wang, Tony Ngo, Ekta Khare, Rezvan Chitsazi, Suchismita Roy, Christopher T. Schafer, Tracy M. Handel, Irina Kufareva

This study compares the conformational dynamics of ACKR3 and CXCR4 using MD simulations and BRET assays, revealing that ACKR3's dynamic behavior leads to activation-proneness and G protein-incompetence.

bioRxiv · May 20, 2026 · PreprintPharmacology & Toxicology

Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28

Mian Huang, Aura F. Celniker, Rezvan Chitsazi, Douglas P. Dyer, Ariane L. Jansma, Irina Kufareva, Catherina L. Salanga, Tracy M. Handel

This study identifies N-terminal determinants of CCL27 and CCL28 receptor activation and selectivity by analyzing mutations and using AlphaFold models.

Journal of Biological Chemistry · Sep 19, 2025Peer-reviewedPharmacology & Toxicology

The 4th GPCR Dock: assessment of blind predictions for GPCR-ligand complexes in the era of AlphaFold

Rezvan Chitsazi, Yiran Wu, GPCR Dock 2021 participants, Raymond C. Stevens, Suwen Zhao, Irina Kufareva

This paper assesses GPCR-ligand complex predictions in the era of AlphaFold, showing AI models can match or exceed low-resolution experimental structures but still need high-resolution data and hybrid methods.

bioRxiv · Apr 18, 2025 · PreprintMolecular Biology