Markus Lindberg

This study uses whole genome sequencing to trace the early origins of small intestine neuroendocrine tumors, showing that major genetic changes and metastases can originate in childhood or adolescence.

The paper analyzes genome sequences from multifocal SI-NET tumors to show they arise from independent clonal origins, lacking shared mutations.

The paper analyzes UV-induced mutational signatures, showing variability across chromatin states and improved modeling with extended sequence patterns.